Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.72 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | RBP4 | P02753 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23712369 | 0.87 | HRH4 (0.75) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL28469741 | 0.85 | HRH4 (0.74) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL2350768 | 0.85 | HRH4 (0.78) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL604932 | 0.84 | HRH4 (1.00) | HRH4HRH3POLBSMN1; SMN2HRH1 | |
| SCHEMBL2345954 | 0.84 | HRH4 (0.76) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL29944207 | 0.84 | HRH4 (0.76) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL2679610 | 0.82 | HRH4 (1.00) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL29699763 | 0.82 | HRH4 (1.00) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL23493675 | 0.82 | HRH4 (0.51) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL3253717 | 0.81 | POLB (1.00) | HRH4HRH3POLBSMN1; SMN2AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101316838-B | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators | HOFFMANN LA ROCHE | 2013-01-30 | — | — | CN | disclosed |
| EP-1968967-B1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2011-04-27 | — | — | EP | disclosed |
| US-7538101-B2 | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-7538101-B2 | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-05-26 | — | — | US | disclosed |
| CN-101316838-A | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | disclosed |
| EP-1968967-A1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007062997-A1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | US | disclosed |
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | MTNR1A, HTR1A, HRH4 | HRH4 3/4885HRH3 4/4885POLB 2909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.