Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.62 |
| ▸ | BTK | Q06187 | 7/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | TEC | P42680 | 1/20 | 0.52 |
| ▸ | TXK | P42681 | 1/20 | 0.52 |
| ▸ | BMX | P51813 | 1/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 4/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | PRKDC | P78527 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 2/20 | 0.48 |
| ▸ | BLK | P51451 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28384616 | 0.94 | BTK (0.59) | MTORHDAC1BTKERBB2TEC | |
| SCHEMBL30172742 | 0.91 | BTK (0.52) | MTORHDAC1BTKERBB2TEC | |
| SCHEMBL28380138 | 0.89 | LMNA (0.51) | MTORHDAC1BTKERBB2TEC | |
| SCHEMBL28471958 | 0.88 | BTK (0.56) | MTORHDAC1BTKERBB2TEC | |
| SCHEMBL28383935 | 0.88 | BTK (0.61) | MTORHDAC1BTKERBB2TEC | |
| SCHEMBL28380136 | 0.88 | BTK (0.55) | MTORHDAC1BTKERBB2TEC | |
| SCHEMBL28473090 | 0.87 | HDAC1 (0.62) | MTORHDAC1BTKFYNPIK3CD | |
| SCHEMBL28382115 | 0.87 | BTK (0.53) | MTORHDAC1BTKERBB2TEC | |
| SCHEMBL28384506 | 0.87 | BTK (0.53) | MTORHDAC1BTKERBB2TEC | |
| SCHEMBL28387491 | 0.85 | BTK (0.61) | MTORHDAC1BTKERBB2TEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662296-B | Hydroxamic acid derivative containing pyrazolopyrimidine and preparation method and application thereof | 山东大学 | 2021-12-31 | — | — | CN | claimed |
| CN-111662296-A | Hydroxamic acid derivative containing pyrazolopyrimidine and preparation method and application thereof | 山东大学 | 2020-09-15 | — | — | CN | claimed |
| CN-111662296-B | Hydroxamic acid derivative containing pyrazolopyrimidine and preparation method and application thereof | 山东大学 | 2021-12-31 | — | — | CN | disclosed |
| CN-111662296-A | Hydroxamic acid derivative containing pyrazolopyrimidine and preparation method and application thereof | 山东大学 | 2020-09-15 | — | — | CN | disclosed |