Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 11/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | RPA1 | P27694 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23294499 | 0.81 | KMO (0.46) | KMOKDM4CRPA1KCNH2 | |
| SCHEMBL16708689 | 0.80 | POLB (0.45) | — | |
| SCHEMBL12989454 | 0.79 | NPC1 (0.41) | KDM4CCNR1 | |
| SCHEMBL28014685 | 0.77 | GPBAR1 (0.57) | SMO | |
| SCHEMBL15897047 | 0.73 | TPMT (0.37) | — | |
| SCHEMBL22608623 | 0.72 | KMO (0.45) | KMORXRARXRBRXRGCNR1 | |
| SCHEMBL29490706 | 0.72 | KMO (0.45) | KMORXRARXRBRXRGCNR1 | |
| SCHEMBL29102516 | 0.71 | SLC6A3 (0.46) | KMOPPP1CASMO | |
| SCHEMBL3540530 | 0.69 | KMO (0.66) | KMORXRARXRBRPA1 | |
| SCHEMBL20659684 | 0.69 | KDM2B (0.47) | KMOKDM2BKDM4CGRM5RPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114258390-A | Glycolate oxidase inhibitors for disease treatment | 生物马林药物股份有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-111788187-A | Glycolate oxidase inhibitors for disease treatment | 生物马林药物股份有限公司 | 2020-10-16 | — | — | CN | disclosed |