Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13411537 | 1.00 | MAPT (0.47) | MAPTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL645065 | 0.83 | ALDH1A1 (0.48) | MAPTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL645064 | 0.83 | ALDH1A1 (0.48) | MAPTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL182255 | 0.81 | ALDH1A1 (0.46) | MAPTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL2719545 | 0.81 | ALDH1A1 (0.46) | MAPTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL182254 | 0.81 | ALDH1A1 (0.46) | MAPTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL176973 | 0.80 | NPC1 (0.48) | MAPTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL13867288 | 0.80 | MAPT (0.45) | MAPTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL13745233 | 0.80 | NPC1 (0.48) | MAPTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL3886895 | 0.80 | MAPT (0.45) | MAPTALDH1A1CYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069341-A1 | TETRAHYDRO-PYRANOPYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-03-18 | — | — | US | disclosed |
| US-20070155723-A1 | Tetrahydro-pyranopyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-05 | — | — | US | disclosed |
| WO-2007001939-A1 | TETRAHYDRO-PYRANOPYRAZOLE COMPOUNDS DISPLAYING CANNABINOID MODULATING ACTIVITIES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155723-A1 | Tetrahydro-pyranopyrazole cannabinoid modulators | CNR2, CNR1, GPR18 | MAPT 1557/4885ALDH1A1 1987/4885CYP1A2 387/4885 |
| US-20100069341-A1 | TETRAHYDRO-PYRANOPYRAZOLE CANNABINOID MODULATORS | CNR2, CNR1, GPR18 | MAPT 1557/4885ALDH1A1 1987/4885CYP1A2 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.