Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 10/20 | 0.33 |
| ▸ | HTR1D | P28221 | 3/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878352 | 0.89 | IL6ST (0.33) | — | |
| SCHEMBL3103739 | 0.85 | AKR1C3 (0.31) | — | |
| SCHEMBL3942531 | 0.84 | HTR6 (0.45) | HTR6HTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL2841737 | 0.84 | HTR6 (0.36) | HTR6 | |
| SCHEMBL2838884 | 0.82 | HTR2A (0.32) | HTR2A | |
| SCHEMBL627039 | 0.79 | HTR2A (0.57) | HTR2AHTR6HTR2CHTR7 | |
| Hydrochloric Acid SCHEMBL8648129 | 0.78 | HTR2A (0.55) | HTR2AHTR6 | |
| SCHEMBL3116935 | 0.76 | TFPI2 (0.34) | — | |
| SCHEMBL4292568 | 0.75 | HTR6 (0.49) | HTR2AHTR6HTR1DHTR1AHTR2C | |
| SCHEMBL625921 | 0.74 | HTR2A (0.42) | HTR2AHTR6HTR1DMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120886-A1 | ARYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-05-13 | — | — | US | claimed |
| US-20100076036-A1 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-03-25 | — | — | US | claimed |
| EP-1953153-A1 | Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders | Laboratorios del Dr. Esteve S.A. (ES) | 2008-08-06 | — | — | EP | claimed |
| US-20100120886-A1 | ARYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-05-13 | — | — | US | disclosed |
| US-20100076036-A1 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-03-25 | — | — | US | disclosed |
| EP-2125721-A1 | ARYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-12-02 | — | — | EP | disclosed |
| EP-2114929-A1 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008092665-A1 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008092666-A1 | ARYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-08-07 | — | — | WO | disclosed |
| EP-1953141-A1 | Aryl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders | Laboratorios del Dr. Esteve S.A. (ES) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953153-A1 | Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders | Laboratorios del Dr. Esteve S.A. (ES) | 2008-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076036-A1 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | HTR6, HTR2A, HTR2C | HTR2A 2/4885HTR6 1/4885HTR1D 18/4885 |
| US-20100120886-A1 | ARYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | HTR6, HTR2A, HTR2C | HTR2A 2/4885HTR6 1/4885HTR1D 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.