Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 8/20 | 0.96 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.96 |
| ▸ | HTR3B | O95264 | 4/20 | 0.96 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.96 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127461 | 0.98 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL5462615 | 0.86 | HTR3E (0.77) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ammonia Solution, Strong SCHEMBL28466868 | 0.85 | HTR3E (0.70) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ammonia Solution, Strong SCHEMBL28500104 | 0.85 | HTR3E (0.70) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL4553876 | 0.82 | HTR3E (0.72) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL31415224 | 0.82 | HTR3E (0.72) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL1515249 | 0.82 | HTR3E (0.72) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL6467644 | 0.81 | HTR3E (0.70) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ammonia Solution, Strong SCHEMBL28507641 | 0.80 | HTR3E (0.64) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL2298133 | 0.79 | HTR3E (0.68) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-111747954-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-112279837-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-112055709-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-111747954-A | Pyrazine compounds and uses thereof | 迪哲（江苏）医药有限公司 | 2020-10-09 | — | — | CN | disclosed |