SCHEMBL28472579

SCHEMBL28472579

O=C(O)c1ccc(CCF)cc1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.53
CASP1 P29466 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
NR1H4 Q96RI1 1/20 0.46
MEN1 O00255 1/20 0.43
RECQL P46063 1/20 0.43
BLM P54132 1/20 0.43
KMT2A Q03164 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
MYC P01106 1/20 0.42
NR4A1 P22736 1/20 0.42
ALDH1A1 P00352 2/20 0.42
LCK P06239 1/20 0.42
PTPRG P23470 2/20 0.41
PTPRC P08575 1/20 0.41
PPARA Q07869 1/20 0.41
TP53 P04637 1/20 0.40
PNMT P11086 1/20 0.40
TAAR1 Q96RJ0 1/20 0.40
CA2 P00918 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27543732 0.86 TAAR1 (0.58) TSHRCASP1SMN1; SMN2NR1H4MEN1
SCHEMBL9192851 0.85 TSHR (0.57) TSHRCASP1SMN1; SMN2NR1H4MEN1
SCHEMBL27605961 0.84 TSHR (0.55) TSHRCASP1SMN1; SMN2NR1H4MEN1
SCHEMBL9952446 0.84 TSHR (0.55) TSHRCASP1SMN1; SMN2NR1H4MEN1
SCHEMBL20077276 0.82 SMN1; SMN2 (0.53) TSHRCASP1SMN1; SMN2NR1H4MEN1
SCHEMBL27810308 0.82 TSHR (0.53) TSHRCASP1SMN1; SMN2NR1H4MEN1
SCHEMBL1293285 0.81 TSHR (0.57) TSHRCASP1SMN1; SMN2NR1H4MYC
SCHEMBL9558139 0.81 TSHR (0.61) TSHRCASP1SMN1; SMN2NR1H4MYC
SCHEMBL28490841 0.80 LCK (0.43) TSHRALDH1A1LCKPPARAKLKB1
SCHEMBL543139 0.79 SMN1; SMN2 (0.59) TSHRCASP1SMN1; SMN2NR1H4MYC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111848406-B Preparation method of 2-chloro-4-fluoro-5-nitrobenzaldehyde 沈阳中化农药化工研发有限公司 2022-03-29 CN disclosed
CN-111848406-A Preparation method of 2-chloro-4-fluoro-5-nitrobenzaldehyde 沈阳中化农药化工研发有限公司 2020-10-30 CN disclosed