SCHEMBL28474253

Cc1cnc(-c2cc(O[C@@H]3CCCN(C(=O)OC(C)(C)C)C3)cc(C(=O)N[C@H](C)c3cnc(C(F)(F)F)nc3)c2)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

	gene	UniProt	supporting neighbours	confidence
▸	P2RX3	P56373	20/20	1.00

▸	P2RX2	Q9UBL9	20/20	1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL28474254	1.00	P2RX3 (1.00)	P2RX3P2RX2
SCHEMBL19962279	1.00	P2RX3 (1.00)	P2RX3P2RX2
SCHEMBL29441060	1.00	P2RX3 (1.00)	P2RX3P2RX2
SCHEMBL19962211	0.96	P2RX3 (0.92)	P2RX3P2RX2
SCHEMBL17823762	0.93	P2RX3 (0.87)	P2RX3P2RX2
SCHEMBL21875523	0.93	P2RX3 (0.87)	P2RX3P2RX2
SCHEMBL23111464	0.92	P2RX3 (1.00)	P2RX3P2RX2
SCHEMBL17823855	0.92	P2RX3 (1.00)	P2RX3P2RX2
SCHEMBL29441222	0.92	P2RX3 (1.00)	P2RX3P2RX2
SCHEMBL23111488	0.92	P2RX3 (0.85)	P2RX3P2RX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-110256418-B	1, 3-thiazol-2-yl substituted benzamides	拜耳公司	2023-01-20	—	—	CN	disclosed
CN-112384213-A	1, 3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization	拜耳公司	2021-02-19	—	—	CN	disclosed
CN-112334132-A	1, 3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization	拜耳公司	2021-02-05	—	—	CN	disclosed
CN-107207507-B	1, 3-thiazol-2-yl substituted benzamides	拜耳公司	2020-11-06	—	—	CN	disclosed