Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 5/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30090297 | 1.00 | RIPK1 (0.38) | RIPK1HDAC4JAK2NTRK1 | |
| SCHEMBL22638823 | 0.84 | RIPK1 (0.51) | RIPK1 | |
| SCHEMBL22638820 | 0.84 | RIPK1 (0.51) | RIPK1 | |
| SCHEMBL22638907 | 0.84 | RIPK1 (0.51) | RIPK1 | |
| Hydrochloric Acid SCHEMBL28931982 | 0.83 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL30090447 | 0.82 | CYP2A6 (0.35) | RIPK1 | |
| SCHEMBL29136717 | 0.82 | CYP2A6 (0.35) | RIPK1 | |
| SCHEMBL28629177 | 0.79 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL30166293 | 0.79 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL30090517 | 0.78 | RIPK1 (0.41) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113767092-B | Di-heterocyclic carbonyl substituted dihydropyrazoles, their preparation and their use in medicine | 劲方医药科技(上海)有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-115605463-A | Inhibitors of receptor interacting protein kinase I for the treatment of diseases | 德州大学系统董事会（US） | 2023-01-13 | — | — | CN | disclosed |
| CN-113767092-A | Bis-heterocyclic carbonyl substituted dihydropyrazole compound, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-113302183-A | Cyclic ureas | 圣瑞诺有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-112370452-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-107624111-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-11-03 | — | — | CN | disclosed |