Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NNMT | P40261 | 4/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27448979 | 0.85 | POLB (0.50) | POLBPLAUTSHRNNMTSIRT6 | |
| SCHEMBL11782158 | 0.83 | PLAU (0.42) | POLBPLAUTSHRNNMTSIRT6 | |
| SCHEMBL30562670 | 0.82 | ALDH1A1 (0.44) | PLAUHSD17B10DAOMEN1KMT2A | |
| SCHEMBL19028056 | 0.82 | ALDH1A1 (0.44) | PLAUHSD17B10DAOMEN1KMT2A | |
| SCHEMBL4144902 | 0.81 | POLB (0.43) | POLBPLAUTSHRNNMTSIRT6 | |
| SCHEMBL30867441 | 0.81 | POLB (0.43) | POLBPLAUTSHRNNMTSIRT6 | |
| SCHEMBL23235003 | 0.80 | POLB (0.40) | POLBPLAUTSHRNNMTSIRT6 | |
| SCHEMBL29804406 | 0.78 | MAPK1 (0.40) | POLBTSHRHSD17B10DAOMAPT | |
| SCHEMBL24683113 | 0.78 | MAPK1 (0.40) | POLBTSHRHSD17B10DAOMAPT | |
| SCHEMBL27904171 | 0.77 | POLB (0.50) | POLBTSHRNNMTSIRT6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111867585-A | Oxadiazole transient receptor potential channel inhibitors | 豪夫迈·罗氏有限公司 | 2020-10-30 | — | — | CN | disclosed |