SCHEMBL28477223

SCHEMBL28477223

CC(NC(=O)c1cc(Cl)cc2ccc(Cc3ccc(C(F)(F)F)cc3)n12)c1ccc(C(=O)O)cc1

nearest known ligand 0.56

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 19/20 0.56
PTGDR Q13258 2/20 0.56
PTGER2 P43116 1/20 0.53
PTGER3 P43115 1/20 0.50
PHGDH O43175 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1956758 1.00 PTGER4 (0.56) PTGER4PTGDRPTGER2PTGER3PHGDH
SCHEMBL1956768 0.90 PTGER4 (0.54) PTGER4PTGDRPTGER2PTGER3
SCHEMBL28484982 0.90 PTGER4 (0.54) PTGER4PTGDRPTGER2PTGER3
SCHEMBL23089016 0.85 PTGER4 (0.49) PTGER4PTGDRPTGER2PTGER3
SCHEMBL23089018 0.85 PTGER4 (0.49) PTGER4PTGDRPTGER2PTGER3
SCHEMBL28474778 0.79 PTGER4 (0.42) PTGER4PTGDRPTGER2PTGER3
SCHEMBL196469 0.78 PTGER4 (0.43) PTGER4PTGDRPTGER2PTGER3
SCHEMBL23089017 0.77 PDE2A (0.41) PTGER4PTGDRPTGER2PTGER3
SCHEMBL196468 0.75 SRD5A2 (0.44) PTGER4PTGDRPTGER2PHGDH
SCHEMBL28933081 0.74 PTGER4 (0.69) PTGER4PTGER3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111936502-A Heterobicyclic carboxylic acids and salts thereof 深圳市原力生命科学有限公司 2020-11-13 CN claimed
CN-111727044-A Heterobicyclic carboxylic acids for the treatment of cancer or inflammatory diseases 深圳市原力生命科学有限公司 2020-09-29 CN claimed
CN-111936502-B Heterobicyclic carboxylic acids and salts thereof 深圳市原力生命科学有限公司 2024-05-31 CN disclosed
CN-117643587-A Heterobicyclic carboxylic acids for the treatment of cancer 深圳市原力生命科学有限公司 2024-03-05 CN disclosed
CN-111936502-A Heterobicyclic carboxylic acids and salts thereof 深圳市原力生命科学有限公司 2020-11-13 CN disclosed