Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phenylpiperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 0.77 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.77 |
| ▸ | HTR3B | O95264 | 4/20 | 0.77 |
| ▸ | HTR3A | P46098 | 4/20 | 0.77 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.77 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.77 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.77 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | HTR6 | P50406 | 4/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylpiperazine SCHEMBL11621472 | 0.88 | ADRB1 (0.83) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL29135595 | 0.88 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL27858598 | 0.88 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL55125 | 0.88 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL24889 | 0.88 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL27492626 | 0.86 | ADRB1 (0.87) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL4828251 | 0.86 | ADRB1 (0.87) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL10675573 | 0.86 | ADRB1 (0.95) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL212247 | 0.86 | ADRB1 (0.95) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL17431870 | 0.86 | ADRB1 (0.95) | ADRB1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114561083-A | Preparation method of piperazinyl phenylphosphate flame-retardant epoxy resin composite material | 南京工业大学 | 2022-05-31 | — | — | CN | claimed |
| CN-112526026-A | Method for detecting chemical component addition in Chinese patent medicine | 北京美康堂医药科技有限公司 | 2021-03-19 | — | — | CN | claimed |
| CN-114561083-A | Preparation method of piperazinyl phenylphosphate flame-retardant epoxy resin composite material | 南京工业大学 | 2022-05-31 | — | — | CN | disclosed |
| CN-114561083-A | Preparation method of piperazinyl phenylphosphate flame-retardant epoxy resin composite material | 南京工业大学 | 2022-05-31 | — | — | CN | disclosed |
| CN-114129527-A | Miniature tablet and preparation method and preparation thereof | 北京微智瑞医药科技有限公司 | 2022-03-04 | — | — | CN | disclosed |
| CN-113788757-B | Pentoxyverine citrate hapten, antigen, antibody, detection device and preparation method | 广东江门中医药职业学院 | 2022-02-18 | — | — | CN | disclosed |
| CN-113788757-A | Pentoxyverine citrate hapten, antigen, antibody, detection device and preparation method | 广东江门中医药职业学院 | 2021-12-14 | — | — | CN | disclosed |
| CN-111902146-A | Medicinal product for treating cough | 日本化学药品株式会社 | 2020-11-06 | — | — | CN | disclosed |