Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.50 |
| ▸ | WNT3A | P56704 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850545 | 0.84 | MEN1 (0.42) | MEN1KMT2AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL1975152 | 0.84 | CA12 (0.65) | KDM4ERAB9ADRD2CYP1A2CYP3A4 | |
| SCHEMBL336061 | 0.84 | DRD2 (0.49) | MEN1KMT2ASMN1; SMN2HPGDDRD2 | |
| SCHEMBL9433997 | 0.84 | DRD2 (0.58) | MEN1KMT2AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL7220917 | 0.83 | CTNNB1 (0.50) | MEN1KMT2ADRD2MAPTCYP1A2 | |
| SCHEMBL1525956 | 0.83 | MAPT (0.59) | MEN1KMT2AKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL3837509 | 0.83 | MAPK1 (0.56) | MEN1KMT2ASMN1; SMN2DRD2MAPT | |
| SCHEMBL4194168 | 0.83 | DRD2 (0.48) | MEN1KMT2ASMN1; SMN2DRD2MAPT | |
| SCHEMBL27779118 | 0.82 | DRD2 (0.47) | MEN1KMT2AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL29578705 | 0.82 | MEN1 (0.73) | MEN1KMT2AKDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340478-B2 | Cooling agent and TRPM8 activator | KAO CORPORATION (JP) | 2016-05-17 | — | — | US | disclosed |
| US-20140329910-A1 | Cooling Agent and TRPM8 Activator | KAO CORPORATION (JP) | 2014-11-06 | — | — | US | disclosed |
| WO-2013080830-A1 | COOLING AGENT AND TRPM8 ACTIVATOR | 花王株式会社 (JP) | 2013-06-06 | — | — | WO | disclosed |
| US-20100160335-A1 | PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | KYORIN PHARMACEUTICAL CO., LTD. | 2010-06-24 | — | — | US | disclosed |
| US-20100160335-A1 | PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | KYORIN PHARMACEUTICAL CO., LTD. | 2010-06-24 | — | — | US | disclosed |
| US-20100130738-A1 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-05-27 | — | — | US | disclosed |
| US-20100130738-A1 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-05-27 | — | — | US | disclosed |
| EP-2168959-A1 | PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | Kyorin Pharmaceutical Co., Ltd. (JP) | 2010-03-31 | — | — | EP | disclosed |
| EP-2168960-A1 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | Kyorin Pharmaceutical Co., Ltd. (JP) | 2010-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130738-A1 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | PDE3A, PDE3B, PDE2A | MEN1 2935/4885KMT2A 1528/4885KDM4E 1383/4885 |
| US-20100160335-A1 | PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | PDE3A, PDE5A, PDE2A | MEN1 2515/4885KMT2A 1733/4885KDM4E 811/4885 |
| US-20140329910-A1 | Cooling Agent and TRPM8 Activator | TRPM8, TRPM7, TRPM6 | MEN1 1329/4885KMT2A 1436/4885KDM4E 3064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.