Sugi Predict

Sugi Predict / Compounds / SCHEMBL2848264

SCHEMBL2848264

SCHEMBL2848264

Cc1cccc(Nc2ccc3cccc(Cl)c3n2)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ XPO1 O14980 2/20 0.54
▸ HSD11B1 P28845 3/20 0.48
▸ MDM2 Q00987 3/20 0.46
▸ RAB9A P51151 3/20 0.43
▸ L3MBTL1 Q9Y468 2/20 0.43
▸ NPC1 O15118 2/20 0.43
▸ TP53 P04637 2/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ ALOX15 P16050 1/20 0.43
▸ TSHR P16473 1/20 0.43
▸ ALOX12 P18054 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ KLF5 Q13887 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43
▸ JAK2 O60674 2/20 0.43
▸ MAP4K4 O95819 1/20 0.43
▸ JAK1 P23458 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1702491 0.85 XPO1 (0.49) XPO1RAB9AL3MBTL1NPC1TP53
SCHEMBL22134943 0.82 XPO1 (0.49) XPO1MDM2RAB9AL3MBTL1NPC1
SCHEMBL3988041 0.81 XPO1 (0.48) XPO1RAB9ANPC1KMT2AHTT
SCHEMBL1702294 0.80 XPO1 (0.50) XPO1RAB9AL3MBTL1NPC1TP53
SCHEMBL29568127 0.80 XPO1 (0.50) XPO1RAB9AL3MBTL1NPC1TP53
SCHEMBL1702529 0.80 XPO1 (0.47) XPO1HSD11B1RAB9AL3MBTL1NPC1
SCHEMBL29110579 0.79 XPO1 (0.52) XPO1RAB9ANPC1TP53KMT2A
SCHEMBL30033495 0.79 KMT2A (0.68) XPO1MDM2RAB9AL3MBTL1NPC1
SCHEMBL1702140 0.79 KMT2A (0.68) XPO1MDM2RAB9AL3MBTL1NPC1
SCHEMBL2757274 0.79 METAP2 (0.59) XPO1MDM2RAB9AL3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2440546-B1 COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA ABIVAX (FR) 2022-12-28 — — EP claimed
EP-2440547-B1 New chemical molecules that inhibit the splicing mechanism for the treatment of diseases resulting from splicing defects ABIVAX (FR) 2022-11-30 — — EP claimed
EP-2440545-B1 COMPOUNDS USEFUL FOR TREATING CANCER ABIVAX (FR) 2019-04-24 — — EP claimed
US-9908869-B2 Compounds useful for treating aids ABIVAX (FR) 2018-03-06 — — US claimed
US-9827237-B2 Compounds useful for treating diseases caused by retroviruses ABIVAX (FR) 2017-11-28 — — US claimed
US-20160151348-A1 COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES ABIVAX (FR) 2016-06-02 — — US claimed
EP-3016656-A1 BICYCLIC COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES ABIVAX (FR) 2016-05-11 — — EP claimed
US-9108919-B2 Compounds useful for treating cancer ABIVAX (FR) 2015-08-18 — — US claimed
WO-2015001518-A1 BICYCLIC COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES SPLICOS (FR) 2015-01-08 — — WO claimed
US-20140288120-A1 COMPOUNDS USEFUL FOR TREATING AIDS SOCIETE SPLICOS (FR) 2014-09-25 — — US claimed
US-20140080831-A1 COMPOUNDS USEFUL FOR TREATING CANCER CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE (FR) 2014-03-20 — — US claimed
US-20120329796-A1 COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA SOCIETE SPLICOS (FR) 2012-12-27 — — US claimed
US-20120283265-A1 COMPOUNDS USEFUL FOR TREATING AIDS SOCIETE SPLICOS (FR) 2012-11-08 — — US claimed
US-20120277230-A1 COMPOUNDS USEFUL FOR TREATING CANCER SOCIETE SPLICOS (FR) 2012-11-01 — — US claimed
CN-102625804-A Compounds for the treatment of AIDS SPLICOS SOC 2012-08-01 — — CN claimed
CN-102596935-A Compounds for the treatment of premature aging and especially premature aging SPLICOS SOC 2012-07-18 — — CN claimed
CN-102574835-A Compounds for the treatment of cancer SPLICOS SOC 2012-07-11 — — CN claimed
WO-2010143169-A2 COMPOUNDS USEFUL FOR TREATING AIDS SOCIÉTÉ SPLICOS (FR) 2010-12-16 — — WO claimed
WO-2010143168-A2 COMPOUNDS USEFUL FOR TREATING CANCER SOCIÉTÉ SPLICOS (FR) 2010-12-16 — — WO claimed
WO-2010143170-A2 COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA SOCIÉTÉ SPLICOS (FR) 2010-12-16 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120283265-A1 COMPOUNDS USEFUL FOR TREATING AIDS CBR1, CNR1, CBR3 XPO1 824/4885HSD11B1 168/4885MDM2 4807/4885
US-20140288120-A1 COMPOUNDS USEFUL FOR TREATING AIDS NR1H3, NR3C1, NR3C2 XPO1 1048/4885HSD11B1 82/4885MDM2 4878/4885
US-20120277230-A1 COMPOUNDS USEFUL FOR TREATING CANCER CBR1, CBR3, NCOR1 XPO1 448/4885HSD11B1 237/4885MDM2 3566/4885
US-20120329796-A1 COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA NR2C2, NCOR2, NR4A2 XPO1 1488/4885HSD11B1 634/4885MDM2 3074/4885
US-20160151348-A1 COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES RCOR1, CBR1, RCOR3 XPO1 761/4885HSD11B1 657/4885MDM2 3865/4885
US-20140080831-A1 COMPOUNDS USEFUL FOR TREATING CANCER NR1H4, NR1H3, NCOR1 XPO1 958/4885HSD11B1 62/4885MDM2 4352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.