SCHEMBL28484041

SCHEMBL28484041

O=C(COc1ccccc1)n1ccc2ccccc21

nearest known ligand 0.60

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 1/20 0.54
▸ KMT2A Q03164 3/20 0.53
▸ MEN1 O00255 2/20 0.53
▸ RAB9A P51151 2/20 0.53
▸ L3MBTL1 Q9Y468 2/20 0.53
▸ TSHR P16473 1/20 0.53
▸ NOTUM Q6P988 1/20 0.51
▸ ALOX15 P16050 1/20 0.49
▸ GAA P10253 2/20 0.46
▸ USP2 O75604 1/20 0.46
▸ HTT P42858 1/20 0.45
▸ NPC1 O15118 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ MCL1 Q07820 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25937249 0.76 NOTUM (0.61) MAPK1KMT2ARAB9AL3MBTL1TSHR
SCHEMBL30760162 0.76 TSHR (0.57) MAPK1KMT2ARAB9AL3MBTL1TSHR
SCHEMBL17287275 0.76 L3MBTL1 (0.57) KMT2AMEN1RAB9AL3MBTL1TSHR
Hydrochloric Acid SCHEMBL25430303 0.75 NOTUM (0.59) MAPK1KMT2ARAB9AL3MBTL1TSHR
SCHEMBL30452280 0.75 NOTUM (0.65) MAPK1KMT2ARAB9AL3MBTL1TSHR
SCHEMBL2997057 0.75 NOTUM (0.65) MAPK1KMT2ARAB9AL3MBTL1TSHR
SCHEMBL10837613 0.75 NOTUM (0.59) MAPK1KMT2ARAB9AL3MBTL1TSHR
SCHEMBL3231404 0.75 KMT2A (0.49) KMT2AMEN1RAB9AL3MBTL1ALOX15
SCHEMBL20376196 0.75 NOTUM (0.51) MAPK1KMT2ARAB9AL3MBTL1TSHR
SCHEMBL931955 0.74 TSHR (0.69) MAPK1KMT2AMEN1RAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117377478-A Methods and compositions for regenerating hair cells in the inner ear of an adult mammal 麻省眼耳科医院 2024-01-09 — — CN disclosed
CN-112359018-A Methods and compositions for regenerating hair cells and/or supporting cells 麻省眼耳医院 2021-02-12 — — CN disclosed
CN-104869987-B Methods and compositions for regenerating hair cells and/or supporting cells 麻省眼耳医院 2020-10-16 — — CN disclosed
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