Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 9/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGFR | P43088 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28491847 | 0.93 | HRH3 (0.38) | CCR3PTGER4PTGDRTBXA2RPTGER1 | |
| SCHEMBL28484362 | 0.89 | NPC1 (0.38) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL28487960 | 0.79 | CYP19A1 (0.39) | KCNH2 | |
| SCHEMBL22276154 | 0.78 | PTGER4 (0.39) | CCR3PTGER4PTGDRTBXA2RPTGER1 | |
| SCHEMBL23890305 | 0.78 | PTGER4 (0.39) | CCR3PTGER4PTGDRTBXA2RPTGER1 | |
| SCHEMBL28487995 | 0.74 | EGLN2 (0.39) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276172 | 0.74 | ATM (0.38) | — | |
| SCHEMBL22276171 | 0.74 | HDAC3 (0.38) | PTGER4PTGDR | |
| SCHEMBL28493532 | 0.74 | PTGER4 (0.48) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL28487481 | 0.73 | HDAC11 (0.42) | PTGER4PTGDRTBXA2RPTGER1PTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111989311-B | Compound for inhibiting PGE2/EP4 signal transduction, preparation method thereof and application thereof in medicines | 凯复(苏州)生物医药有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-111989311-A | Compound for inhibiting PGE2/EP4 signal transduction, preparation method thereof and application thereof in medicines | 凯复(苏州)生物医药有限公司 | 2020-11-24 | — | — | CN | disclosed |