Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 2/20 | 0.41 |
| ▸ | TPO | P07202 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | EPX | P11678 | 1/20 | 0.41 |
| ▸ | MGMT | P16455 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997227 | 0.76 | TTK (0.50) | CYP3A4CDC7MAPK1ALDH1A1HPGD | |
| SCHEMBL28378989 | 0.76 | PARP1 (0.43) | MPOCYP3A4ALDH1A1HPGDHTT | |
| SCHEMBL847077 | 0.70 | LMNA (0.47) | CNR1CNR2MGMTCDC7DBF4 | |
| SCHEMBL6997886 | 0.68 | ALDH1A1 (0.46) | CYP3A4MAPK1ALDH1A1LMNAHPGD | |
| SCHEMBL5440113 | 0.68 | KDM4C (0.47) | MPOTPOCYP3A4EPXMGMT | |
| SCHEMBL31261712 | 0.67 | ALDH1A1 (0.48) | CNR1CNR2CDC7DBF4MAPK1 | |
| SCHEMBL9980485 | 0.67 | GRM4 (0.63) | CYP3A4MAPK1TSHR | |
| SCHEMBL22890209 | 0.67 | CNR2 (0.52) | CNR1CNR2HTR2CHTR2BMPO | |
| SCHEMBL875608 | 0.67 | LMNA (0.53) | MAPK1LMNAL3MBTL1PRMT5 | |
| SCHEMBL1014840 | 0.66 | CHEK1 (0.47) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112010860-B | Benzyloxypyrazolopyrimidine compounds, pharmaceutical compositions and uses thereof | 南京纳丁菲医药科技有限公司 | 2023-03-10 | — | — | CN | claimed |
| CN-112010860-A | Benzyloxypyrazolopyrimidine compounds, pharmaceutical compositions and uses thereof | 南京纳丁菲医药科技有限公司 | 2020-12-01 | — | — | CN | claimed |
| CN-112010860-B | Benzyloxypyrazolopyrimidine compounds, pharmaceutical compositions and uses thereof | 南京纳丁菲医药科技有限公司 | 2023-03-10 | — | — | CN | disclosed |
| CN-112010860-B | Benzyloxypyrazolopyrimidine compounds, pharmaceutical compositions and uses thereof | 南京纳丁菲医药科技有限公司 | 2023-03-10 | — | — | CN | disclosed |
| CN-112010860-B | Benzyloxypyrazolopyrimidine compounds, pharmaceutical compositions and uses thereof | 南京纳丁菲医药科技有限公司 | 2023-03-10 | — | — | CN | disclosed |
| CN-112010860-A | Benzyloxypyrazolopyrimidine compounds, pharmaceutical compositions and uses thereof | 南京纳丁菲医药科技有限公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-112010860-A | Benzyloxypyrazolopyrimidine compounds, pharmaceutical compositions and uses thereof | 南京纳丁菲医药科技有限公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-112010860-A | Benzyloxypyrazolopyrimidine compounds, pharmaceutical compositions and uses thereof | 南京纳丁菲医药科技有限公司 | 2020-12-01 | — | — | CN | disclosed |