Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | PDE6D | O43924 | 2/20 | 0.55 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.55 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 6/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412017 | 1.00 | PKN1 (0.56) | PKN1PKN2ALDH1A1PDE6DALDH2 | |
| SCHEMBL29412060 | 0.93 | PKN1 (0.54) | PKN1PKN2ALDH1A1PDE6DALDH2 | |
| SCHEMBL28478408 | 0.93 | ALDH1A1 (0.58) | PKN1PKN2ALDH1A1PDE6DALDH2 | |
| SCHEMBL29412071 | 0.92 | TP53 (0.61) | PKN1PKN2ALDH1A1PDE6DALDH2 | |
| SCHEMBL28487660 | 0.92 | TP53 (0.61) | PKN1PKN2ALDH1A1PDE6DALDH2 | |
| SCHEMBL28484147 | 0.92 | PARP1 (0.51) | PKN1PKN2ALDH1A1PDE6DALDH2 | |
| SCHEMBL29411964 | 0.92 | PARP1 (0.51) | PKN1PKN2ALDH1A1PDE6DALDH2 | |
| SCHEMBL28487655 | 0.91 | ALDH1A1 (0.50) | PKN1PKN2ALDH1A1PDE6DALDH2 | |
| SCHEMBL29411936 | 0.91 | ALDH1A1 (0.50) | PKN1PKN2ALDH1A1PDE6DALDH2 | |
| SCHEMBL29412051 | 0.90 | ALDH1A1 (0.48) | PKN1PKN2ALDH1A1PDE6DALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978301-B | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2022-08-02 | — | — | CN | disclosed |
| CN-111978301-A | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2020-11-24 | — | — | CN | disclosed |