Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 4/20 | 0.38 |
| ▸ | GABRD | O14764 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.38 |
| ▸ | GABRE | P78334 | 4/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28488276 | 0.86 | TNKS (0.48) | TNKSAURKAMAPTLMNAGABRP | |
| SCHEMBL28495324 | 0.81 | TNKS (0.48) | TNKSAURKAALDH1A1 | |
| SCHEMBL30615332 | 0.80 | TNKS (0.45) | TNKSAURKAMAPTMAP4K1CHRM2 | |
| SCHEMBL21464096 | 0.80 | TNKS (0.45) | TNKSAURKAMAPTMAP4K1CHRM2 | |
| SCHEMBL21464095 | 0.80 | TNKS (0.45) | TNKSAURKAMAPTMAP4K1CHRM2 | |
| SCHEMBL30615602 | 0.80 | TNKS (0.45) | TNKSAURKAMAPTMAP4K1CHRM2 | |
| SCHEMBL21464106 | 0.80 | TNKS (0.45) | TNKSAURKAMAPTMAP4K1CHRM2 | |
| SCHEMBL21463400 | 0.80 | MCHR1 (0.46) | TNKSPIK3CA | |
| SCHEMBL21463402 | 0.80 | MCHR1 (0.46) | TNKSPIK3CA | |
| SCHEMBL30615420 | 0.80 | MCHR1 (0.46) | TNKSPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |
| CN-111868037-A | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2020-10-30 | — | — | CN | disclosed |