Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | USP14 | P54578 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21464106 | 1.00 | TNKS (0.45) | TNKSMCHR1MAPK8CDK4CDK6 | |
| SCHEMBL21464096 | 1.00 | TNKS (0.45) | TNKSMCHR1MAPK8CDK4CDK6 | |
| SCHEMBL30615602 | 1.00 | TNKS (0.45) | TNKSMCHR1MAPK8CDK4CDK6 | |
| SCHEMBL21464095 | 1.00 | TNKS (0.45) | TNKSMCHR1MAPK8CDK4CDK6 | |
| SCHEMBL21463400 | 0.84 | MCHR1 (0.46) | TNKSMCHR1 | |
| SCHEMBL30615420 | 0.84 | MCHR1 (0.46) | TNKSMCHR1 | |
| SCHEMBL21463402 | 0.84 | MCHR1 (0.46) | TNKSMCHR1 | |
| SCHEMBL28488276 | 0.82 | TNKS (0.48) | TNKSCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL28488291 | 0.80 | TNKS (0.48) | TNKSCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL21463922 | 0.80 | ALDH1A1 (0.54) | TNKSCHRM2CHRM4CHRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |