SCHEMBL284886

SCHEMBL284886

C[C@H]1O[C@@H](n2cc(F)c(NC(=O)OCCc3ccccc3)nc2=O)[C@H](O)[C@@H]1O

nearest known ligand 0.73

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.73
ADK P55263 3/20 0.49
P2RY6 Q15077 3/20 0.46
P2RY14 Q15391 2/20 0.46
NT5E P21589 1/20 0.46
TSHR P16473 1/20 0.42
MAPT P10636 1/20 0.42
PMP22 Q01453 1/20 0.42
HBB P68871 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NAAA Q02083 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8193617 1.00 LMNA (0.73) LMNAADKP2RY6P2RY14NT5E
SCHEMBL285574 0.95 LMNA (0.76) LMNAADKP2RY6P2RY14NT5E
SCHEMBL9410767 0.95 LMNA (0.76) LMNAADKP2RY6P2RY14NT5E
SCHEMBL9218284 0.91 LMNA (0.70) LMNAADKP2RY6P2RY14NT5E
SCHEMBL9222549 0.91 LMNA (0.70) LMNAADKP2RY6P2RY14NT5E
SCHEMBL3819600 0.89 LMNA (0.58) LMNAADKP2RY6NAAA
SCHEMBL285147 0.88 LMNA (0.79) LMNAADKP2RY6P2RY14NT5E
SCHEMBL9410640 0.88 LMNA (0.79) LMNAADKP2RY6P2RY14NT5E
SCHEMBL3821161 0.87 LMNA (0.56) LMNAADKP2RY6P2RY14NT5E
SCHEMBL285379 0.87 LMNA (0.87) LMNAADKP2RY6P2RY14NT5E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2428213-A1 STABILIZED CHLORITE SOLUTIONS IN COMBINATION WITH FLUOROPYRIMIDINES FOR USE IN CANCER TREATMENT Nuvo Research AG (CH) 2012-03-14 EP claimed
EP-0882734-B1 5'-Deoxy-cytidine derivatives HOFFMANN LA ROCHE (CH) 2009-08-26 EP claimed
EP-1060183-B1 5'-DEOXYCYTIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2003-04-23 EP claimed
US-6211166-B1 COADMINISTERED WITH A 5-FLUOROURACIL DERIVATIVE; ANTICARCINOGENIC AGENTS HOFFMAN-LA ROCHE INC. 2001-04-03 US claimed
EP-1060183-A1 5'-DEOXYCYTIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2000-12-20 EP claimed
WO-1999040099-A1 5'-DEOXYCYTIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-08-12 WO claimed
EP-0882734-A2 5'-Deoxy-cytidine derivatives F. HOFFMANN-LA ROCHE AG (CH) 1998-12-09 EP claimed
EP-0602454-B1 N-Oxycarbonyl substituted 5'-deoxy-5-fluorocytidines HOFFMANN LA ROCHE (CH) 1996-04-24 EP claimed
EP-0602454-A1 N-Oxycarbonyl substituted 5'-deoxy-5-fluorocytidines F. HOFFMANN-LA ROCHE AG (CH) 1994-06-22 EP claimed
EP-2428213-A1 STABILIZED CHLORITE SOLUTIONS IN COMBINATION WITH FLUOROPYRIMIDINES FOR USE IN CANCER TREATMENT Nuvo Research AG (CH) 2012-03-14 EP disclosed
EP-0882734-B1 5'-Deoxy-cytidine derivatives HOFFMANN LA ROCHE (CH) 2009-08-26 EP disclosed
EP-1060183-B1 5'-DEOXYCYTIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2003-04-23 EP disclosed
US-6211166-B1 COADMINISTERED WITH A 5-FLUOROURACIL DERIVATIVE; ANTICARCINOGENIC AGENTS HOFFMAN-LA ROCHE INC. 2001-04-03 US disclosed
EP-1060183-A1 5'-DEOXYCYTIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2000-12-20 EP disclosed
WO-1999040099-A1 5'-DEOXYCYTIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-08-12 WO disclosed
EP-0882734-A2 5'-Deoxy-cytidine derivatives F. HOFFMANN-LA ROCHE AG (CH) 1998-12-09 EP disclosed
EP-0602454-B1 N-Oxycarbonyl substituted 5'-deoxy-5-fluorocytidines HOFFMANN LA ROCHE (CH) 1996-04-24 EP disclosed
EP-0602454-A1 N-Oxycarbonyl substituted 5'-deoxy-5-fluorocytidines F. HOFFMANN-LA ROCHE AG (CH) 1994-06-22 EP disclosed