SCHEMBL28488641

SCHEMBL28488641

COc1ccc(CN2CCN(c3cncc(OC(N)=O)c3)C2=O)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 7/20 0.56
PKM P14618 1/20 0.45
ALDH1A1 P00352 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C19 P33261 1/20 0.43
SCD O00767 1/20 0.42
RAB9A P51151 2/20 0.42
KDM4E B2RXH2 2/20 0.40
HPGD P15428 2/20 0.40
GAA P10253 1/20 0.40
NPC1 O15118 1/20 0.39
LMNA P02545 1/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22574233 0.86 HDAC1 (0.55) HDAC1PKMALDH1A1SMN1; SMN2CYP1A2
SCHEMBL28482745 0.85 HDAC1 (0.46) HDAC1PKMSCDRAB9ALMNA
SCHEMBL22574084 0.83 HDAC1 (0.57) HDAC1PKMALDH1A1SMN1; SMN2CYP1A2
SCHEMBL22574329 0.82 HDAC1 (0.57) HDAC1PKMALDH1A1SMN1; SMN2CYP1A2
SCHEMBL7823979 0.78 HDAC1 (0.56) HDAC1PKMSCDRAB9AKDM4E
SCHEMBL23771052 0.78 HDAC1 (0.52) HDAC1PKMALDH1A1SMN1; SMN2CYP1A2
SCHEMBL30196013 0.78 HDAC1 (0.52) HDAC1PKMALDH1A1SMN1; SMN2CYP1A2
SCHEMBL28482762 0.77 CYP11B2 (0.49) HDAC1
SCHEMBL8913255 0.72 HDAC1 (0.67) HDAC1PKMALDH1A1CYP2C19RAB9A
SCHEMBL23121322 0.72 CMA1 (0.45) HDAC1ALDH1A1KDM4EGAAHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111936484-A Chromenopyridine derivatives as inhibitors of phosphatidylinositol phosphokinase 拉文纳制药公司 2020-11-13 CN disclosed