Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473754 | 0.81 | CA1 (0.58) | HTTSMN1; SMN2CA1CA2CA9 | |
| SCHEMBL1679566 | 0.80 | ALDH1A1 (0.45) | SMN1; SMN2CA1CA2CA9ALDH1A1 | |
| SCHEMBL24269890 | 0.79 | HTT (0.48) | HTTSMN1; SMN2CA1CA2CA9 | |
| SCHEMBL25983804 | 0.78 | ALOX15 (0.43) | HTTSMN1; SMN2CA1CA2CA9 | |
| SCHEMBL29897650 | 0.77 | HSP90AA1 (0.43) | CA1CA2CA9HIF1A | |
| SCHEMBL24269927 | 0.77 | SMN1; SMN2 (0.45) | HTTSMN1; SMN2CA1CA2CA9 | |
| SCHEMBL21911540 | 0.76 | USP30 (0.49) | HTTSMN1; SMN2CA1CA2CA9 | |
| SCHEMBL881333 | 0.75 | ALDH1A1 (0.44) | CA1CA2CA9ALDH1A1HPGD | |
| SCHEMBL3201071 | 0.75 | CA1 (0.46) | CA1CA2CA9ALDH1A1KDM4E | |
| SCHEMBL31144570 | 0.74 | POLB (0.57) | HTTSMN1; SMN2CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |