Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1L | O00429 | 3/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | PTGFR | P43088 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | GRK2 | P25098 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.32 |
| ▸ | CD38 | P28907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28494628 | 0.88 | PTGER4 (0.37) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL28480177 | 0.86 | KCNH2 (0.36) | DNM1LPTGER4PTGDRTBXA2RPTGER1 | |
| SCHEMBL28485215 | 0.84 | MERTK (0.38) | WNT1GSK3BDYRK1A | |
| SCHEMBL28493538 | 0.82 | CBLB (0.34) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL28487314 | 0.81 | PTGER4 (0.35) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL28484338 | 0.80 | PIK3CA (0.34) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276147 | 0.80 | TBXA2R (0.36) | DNM1LPDPK1ROCK2PTGER4PTGDR | |
| SCHEMBL22276230 | 0.79 | TBXA2R (0.36) | DNM1LPDPK1ROCK2PTGER4PTGDR | |
| SCHEMBL28491854 | 0.77 | FLT1 (0.42) | — | |
| SCHEMBL28487481 | 0.77 | HDAC11 (0.42) | PTGER4PTGDRTBXA2RPTGER1PTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111989311-B | Compound for inhibiting PGE2/EP4 signal transduction, preparation method thereof and application thereof in medicines | 凯复(苏州)生物医药有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-111989311-A | Compound for inhibiting PGE2/EP4 signal transduction, preparation method thereof and application thereof in medicines | 凯复(苏州)生物医药有限公司 | 2020-11-24 | — | — | CN | disclosed |