Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | PTGFR | P43088 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28485215 | 0.88 | MERTK (0.38) | MAPK1 | |
| SCHEMBL28494628 | 0.84 | PTGER4 (0.37) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL28493538 | 0.82 | CBLB (0.34) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL28480177 | 0.81 | KCNH2 (0.36) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276148 | 0.81 | TBXA2R (0.34) | PIK3CAMTORATMATRHCRTR2 | |
| SCHEMBL23890360 | 0.81 | TBXA2R (0.34) | HCRTR2PTGER4PTGDRTBXA2RPTGER1 | |
| SCHEMBL22276183 | 0.80 | TBXA2R (0.33) | PIK3CAMTORATMATRPTGER4 | |
| SCHEMBL28492006 | 0.80 | DNM1L (0.35) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL23890380 | 0.79 | TBXA2R (0.33) | PIK3CAMTORATMATRPTGER4 | |
| SCHEMBL28487314 | 0.77 | PTGER4 (0.35) | PTGER4PTGDRTBXA2RPTGER1PTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111989311-B | Compound for inhibiting PGE2/EP4 signal transduction, preparation method thereof and application thereof in medicines | 凯复(苏州)生物医药有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-111989311-A | Compound for inhibiting PGE2/EP4 signal transduction, preparation method thereof and application thereof in medicines | 凯复(苏州)生物医药有限公司 | 2020-11-24 | — | — | CN | disclosed |