SCHEMBL28492020

SCHEMBL28492020

COc1ccc(S)c(-c2ccccc2C)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 6/20 0.44
CYP2C19 P33261 4/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2A6 P11509 1/20 0.44
GPR3 P46089 1/20 0.43
NR1H4 Q96RI1 1/20 0.42
ABL1 P00519 1/20 0.42
ABCB1 P08183 1/20 0.42
BCR P11274 1/20 0.42
GAA P10253 2/20 0.41
PDK2 Q15119 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2D6 P10635 2/20 0.40
TSHR P16473 2/20 0.40
ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21480791 0.86 CYP1A2 (0.48) CYP1A2CYP2C19CYP2C9CYP2A6GPR3
SCHEMBL28492019 0.84 GPR3 (0.46) CYP1A2CYP2C19CYP2C9CYP2A6GPR3
SCHEMBL8817717 0.81 HDAC4 (0.59) CYP1A2CYP2C19CYP2C9CYP2A6GAA
SCHEMBL5612549 0.80 CYP1A2 (0.43) CYP1A2CYP2C19CYP2C9CYP2A6GPR3
SCHEMBL29083062 0.80 GAA (0.52) CYP1A2CYP2C19CYP2C9GAAPDK2
SCHEMBL28762102 0.79 BACE1 (0.50) CYP1A2CYP2C19CYP2C9CYP2A6ABL1
SCHEMBL8819682 0.78 CYP1A2 (0.58) CYP1A2CYP2C19CYP2C9CYP2A6GPR3
SCHEMBL1528920 0.76 CD274 (0.48) CYP1A2CYP2C19CYP2C9CYP2A6GPR3
SCHEMBL672015 0.76 CA12 (0.46) CYP1A2CYP2A6GAAMEN1KMT2A
SCHEMBL2911817 0.76 CA12 (0.46) CYP1A2CYP2A6GAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108102103-B Preparation method and application of micromolecular phosphate additive 江苏苏博特新材料股份有限公司 2020-12-29 CN disclosed