Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 3/20 | 0.40 |
| ▸ | GABRD | O14764 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.40 |
| ▸ | GABRE | P78334 | 3/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21463678 | 0.87 | HSP90AA1 (0.46) | HSP90AA1TP53LMNAMEN1KMT2A | |
| SCHEMBL21467291 | 0.79 | HSP90AA1 (0.46) | HSP90AA1TP53LMNAMEN1KMT2A | |
| SCHEMBL30615322 | 0.79 | ADORA3 (0.52) | ADORA3HSP90AA1LMNAGABRPGABRD | |
| SCHEMBL28488324 | 0.79 | ADORA3 (0.52) | ADORA3HSP90AA1LMNAGABRPGABRD | |
| SCHEMBL28492436 | 0.74 | SMN1; SMN2 (0.57) | ADORA3LMNAMEN1KMT2AKDM4E | |
| SCHEMBL30615427 | 0.73 | AURKA (0.47) | ADORA3HSP90AA1LMNAMEN1KMT2A | |
| SCHEMBL30615486 | 0.73 | AURKA (0.46) | HSP90AA1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL5956569 | 0.72 | RAB9A (0.55) | ADORA3LMNAKMT2AL3MBTL1GABRP | |
| SCHEMBL21463825 | 0.72 | MAPT (0.49) | HSP90AA1TP53LMNAKDM4EALDH1A1 | |
| SCHEMBL21463740 | 0.72 | ADORA3 (0.46) | ADORA3HSP90AA1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |
| CN-111868037-A | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2020-10-30 | — | — | CN | disclosed |