Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PPP5C | P53041 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18693576 | 1.00 | HTT (0.49) | HTTLMNAHSD17B10PPP5CKDM4E | |
| SCHEMBL18426921 | 0.85 | — | — | |
| SCHEMBL5592744 | 0.85 | — | — | |
| SCHEMBL5592746 | 0.85 | — | — | |
| SCHEMBL13779938 | 0.85 | HTT (0.47) | HTTLMNAHSD17B10 | |
| SCHEMBL18426444 | 0.82 | HSD11B1 (0.55) | HSD17B10 | |
| SCHEMBL18426445 | 0.82 | HSD11B1 (0.55) | HSD17B10 | |
| SCHEMBL19416041 | 0.82 | HTT (0.49) | HTT | |
| SCHEMBL19416085 | 0.82 | HTT (0.49) | HTT | |
| SCHEMBL8194282 | 0.80 | HTT (0.53) | HTTLMNAPPP5CKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108513574-B | N-sulfonylated pyrazolo [3, 4-b ] pyridine-6-carboxamides and methods of use | 艾伯维公司 | 2021-01-05 | — | — | CN | disclosed |