⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18426921 | 1.00 | — | — | |
| SCHEMBL5592746 | 1.00 | — | — | |
| SCHEMBL4019094 | 0.94 | HPGD (0.50) | — | |
| SCHEMBL29165074 | 0.85 | CHRNB2 (0.52) | — | |
| SCHEMBL27144047 | 0.85 | CHRNB2 (0.52) | — | |
| SCHEMBL18693576 | 0.85 | HTT (0.49) | — | |
| SCHEMBL28495248 | 0.85 | HTT (0.49) | — | |
| SCHEMBL4883882 | 0.85 | ALDH1A1 (0.44) | — | |
| SCHEMBL4883884 | 0.85 | ALDH1A1 (0.44) | — | |
| SCHEMBL27147734 | 0.85 | CHRNB2 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2905032-B1 | METHOD AND PHARMACEUTICAL COMPOSITION FOR INHIBITING PI3K/AKT/MTOR SIGNAL PATH | TARGETED THERAPEUTICS LLC (US) | 2018-09-05 | — | — | EP | disclosed |
| CN-103705925-B | Pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway | 段磊 | 2018-03-30 | — | — | CN | disclosed |
| US-9750728-B2 | Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway | TARGETED THERAPEUTICS, LLC (US) | 2017-09-05 | — | — | US | disclosed |
| US-20170119747-A1 | METHOD AND PHARMACEUTICAL COMPOSITION FOR INHIBITING PI3K/AKT/MTOR SIGNALING PATHWAY | TARGETED THERAPEUTICS, LLC | 2017-05-04 | — | — | US | disclosed |
| WO-2017017630-A1 | NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS | HETERO RESEARCH FOUNDATION (IN) | 2017-02-02 | — | — | WO | disclosed |
| EP-2905032-A1 | METHOD AND PHARMACEUTICAL COMPOSITION FOR INHIBITING PI3K/AKT/MTOR SIGNAL PATH | Targeted Therapeutics, LLC (US) | 2015-08-12 | — | — | EP | disclosed |
| CN-103705925-A | Pharmaceutical combinations and methods for inhibiting PI3K/AKT/mTOR signaling pathway | DUAN LEI | 2014-04-09 | — | — | CN | disclosed |
| WO-2007025775-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |
| US-6764858-B2 | GENERATING LIBRARY OF PREFERENTIAL PARTICLES; OBTAIN COMPOUNDS, MONITOR SOLUBILITY IN DEUTERATED WATER, RECOVER CMPOUNDS | PHARMACIA & UPJOHN COMPANY | 2004-07-20 | — | — | US | disclosed |
| US-20020192707-A1 | Methods for creating a compound library | PHARMACIA & UPJOHN | 2002-12-19 | — | — | US | disclosed |