Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16636878 | 0.82 | NT5E (0.36) | NT5EMAPTLMNA | |
| SCHEMBL30656089 | 0.82 | NT5E (0.36) | NT5EMAPTLMNA | |
| SCHEMBL20641687 | 0.82 | KDM1A (0.36) | NT5EKDM1AKDM1BMAPTESR1 | |
| SCHEMBL29487315 | 0.74 | HTT (0.35) | KDM1AKDM1B | |
| SCHEMBL2724749 | 0.74 | HTT (0.35) | KDM1AKDM1B | |
| SCHEMBL14690825 | 0.74 | MAPT (0.40) | NT5EMAPTESR1ESR2LMNA | |
| SCHEMBL28499601 | 0.74 | AXL (0.38) | MAPT | |
| SCHEMBL15647874 | 0.74 | EGFR (0.38) | MAPT | |
| SCHEMBL26998825 | 0.73 | ACHE (0.40) | NT5EMAPTESR1ESR2LMNA | |
| SCHEMBL24252971 | 0.73 | KDM1A (0.33) | KDM1AKDM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112110918-B | Spiro substituted pyrimido cyclic compounds, process for their preparation and their use in medicine | 劲方医药科技(上海)有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-112110918-A | Spiro-substituted pyrimido-cyclic compounds, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2020-12-22 | — | — | CN | disclosed |