SCHEMBL28495804

SCHEMBL28495804

C[C@@H](c1ccccc1)N1C(=O)c2cccc3c(Br)ccc(c23)C1=O

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1B1 Q16678 15/20 0.56
ALDH1A1 P00352 2/20 0.49
POLB P06746 2/20 0.49
RXFP1 Q9HBX9 1/20 0.49
LMNA P02545 2/20 0.48
KDM4E B2RXH2 1/20 0.48
MEN1 O00255 1/20 0.48
NPC1 O15118 1/20 0.48
MAPT P10636 1/20 0.48
PABPC1 P11940 1/20 0.48
KMT2A Q03164 1/20 0.48
TP53 P04637 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
THRB P10828 1/20 0.46
TLR9 Q9NR96 1/20 0.46
S1PR2 O95136 1/20 0.46
MAPK1 P28482 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28502289 1.00 CYP1B1 (0.56) CYP1B1ALDH1A1POLBRXFP1LMNA
SCHEMBL13878053 0.82 ALDH1A1 (0.46) ALDH1A1POLBLMNAKDM4EMAPT
SCHEMBL29575259 0.81 CYP1B1 (0.60) CYP1B1ALDH1A1POLBRXFP1LMNA
SCHEMBL14036086 0.79 ALDH1A1 (0.42) ALDH1A1POLBLMNAKDM4EKMT2A
SCHEMBL13754606 0.78 DNMT3A (0.42) CYP1B1ALDH1A1POLBLMNAMAPT
SCHEMBL607042 0.78 LMNA (0.58) ALDH1A1POLBLMNATP53
SCHEMBL29393294 0.78 LMNA (0.58) ALDH1A1POLBLMNATP53
SCHEMBL6925572 0.78 LMNA (0.58) ALDH1A1POLBLMNATP53
SCHEMBL1518037 0.78 ALDH1A1 (0.68) CYP1B1ALDH1A1POLBRXFP1LMNA
SCHEMBL13923575 0.77 ALDH1A1 (0.43) ALDH1A1POLBLMNAKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112110919-A Chiral thermal activation delayed fluorescent material and preparation method and application thereof 深圳大学 2020-12-22 CN disclosed