Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 7/20 | 0.51 |
| ▸ | CNR1 | P21554 | 5/20 | 0.51 |
| ▸ | ACHE | P22303 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | F2R | P25116 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30615548 | 1.00 | MAPT (0.53) | MAPTPOLBATMCNR2CNR1 | |
| SCHEMBL14923447 | 0.88 | CNR2 (0.52) | MAPTPOLBATMCNR2CNR1 | |
| SCHEMBL264907 | 0.85 | ADORA2A (0.54) | MAPTCNR2CNR1ACHEL3MBTL1 | |
| SCHEMBL14923635 | 0.84 | CNR2 (0.55) | MAPTCNR2CNR1ACHEL3MBTL1 | |
| SCHEMBL11696698 | 0.84 | MAPT (0.53) | MAPTPOLBATMCNR2CNR1 | |
| SCHEMBL27822249 | 0.84 | MAPT (0.46) | MAPTPOLBATMCNR2CNR1 | |
| SCHEMBL30615360 | 0.81 | CNR2 (0.52) | MAPTCNR2CNR1ACHEL3MBTL1 | |
| SCHEMBL28496722 | 0.81 | CNR2 (0.52) | MAPTCNR2CNR1ACHEL3MBTL1 | |
| SCHEMBL14923501 | 0.80 | MAPT (0.45) | MAPTPOLBCNR2CNR1ACHE | |
| SCHEMBL29741986 | 0.80 | L3MBTL1 (0.63) | MAPTPOLBATMCNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |
| CN-111868037-A | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2020-10-30 | — | — | CN | disclosed |