Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22396772 | 0.83 | LMNA (0.51) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL22723792 | 0.81 | MEN1 (0.42) | KMT2AMEN1POLBBLMTDP1 | |
| SCHEMBL27002749 | 0.77 | POLB (0.41) | KMT2AMEN1POLBBLMTDP1 | |
| SCHEMBL15881098 | 0.77 | KMT2A (0.41) | KMT2AMEN1ALDH1A1PLAUSIRT6 | |
| SCHEMBL22617041 | 0.76 | PTPN1 (0.40) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL1818582 | 0.75 | LMNA (0.50) | KMT2AMEN1POLBALDH1A1PLAU | |
| SCHEMBL1031505 | 0.75 | MAPT (0.58) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL2760862 | 0.73 | TUBB4A (0.43) | ALDH1A1PLAUMAPK1SIRT6 | |
| Hydrochloric Acid SCHEMBL8781907 | 0.73 | MAPT (0.57) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL20520312 | 0.73 | GRM2 (0.41) | ALDH1A1PLAUSIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114401952-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-112189008-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2021-01-05 | — | — | CN | disclosed |