Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 6/20 | 0.69 |
| ▸ | EGFR | P00533 | 7/20 | 0.67 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SIK1 | P57059 | 1/20 | 0.48 |
| ▸ | MELK | Q14680 | 1/20 | 0.48 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.48 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374616 | 0.92 | FGFR3 (0.82) | FGFR3EGFRERBB3FGFR1SIK1 | |
| SCHEMBL29159204 | 0.85 | FGFR3 (0.51) | FGFR3EGFRERBB3FGFR1MEN1 | |
| SCHEMBL374531 | 0.84 | FGFR3 (0.79) | FGFR3EGFRERBB3FGFR1MEN1 | |
| SCHEMBL374803 | 0.83 | FGFR3 (0.69) | FGFR3EGFRERBB3FGFR1SIK1 | |
| SCHEMBL374370 | 0.83 | FGFR3 (0.82) | FGFR3EGFRERBB3SIK1MELK | |
| SCHEMBL28498357 | 0.82 | EGFR (0.66) | FGFR3EGFRERBB3FGFR1MEN1 | |
| SCHEMBL374587 | 0.82 | FGFR3 (1.00) | FGFR3EGFRERBB3FGFR1SIK1 | |
| SCHEMBL374127 | 0.82 | FGFR3 (0.75) | FGFR3EGFRERBB3MEN1KMT2A | |
| SCHEMBL28497440 | 0.82 | EGFR (0.60) | FGFR3EGFRERBB3FGFR1MEN1 | |
| SCHEMBL374550 | 0.80 | FGFR3 (1.00) | FGFR3EGFRERBB3FGFR1SIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053592-B | 1- (2, 5-dimethoxyphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof | 温州医科大学 | 2020-12-04 | — | — | CN | claimed |
| CN-109053592-B | 1- (2, 5-dimethoxyphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof | 温州医科大学 | 2020-12-04 | — | — | CN | disclosed |