Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 10/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28498983 | 0.88 | EGFR (0.40) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL21464302 | 0.87 | GABRP (0.38) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL30615616 | 0.87 | GABRP (0.38) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL31050029 | 0.74 | DGAT1 (0.40) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL28506125 | 0.73 | GABRP (0.39) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL30615619 | 0.73 | GABRP (0.39) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL29581588 | 0.71 | PIK3CA (0.34) | NPC1 | |
| SCHEMBL30615635 | 0.70 | GABRP (0.41) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL28903329 | 0.70 | GABRP (0.41) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL21463417 | 0.70 | DGAT1 (0.38) | NPC1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |
| CN-111868037-A | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2020-10-30 | — | — | CN | disclosed |