Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122648 | 0.86 | PDE10A (0.53) | GPR119MAPTALDH1A1LMNAPOLB | |
| SCHEMBL2385593 | 0.83 | GPR119 (0.50) | GPR119MAPTALDH1A1LMNAPOLB | |
| SCHEMBL23560764 | 0.83 | GPR119 (0.50) | SMN1; SMN2GPR119MAPTALDH1A1LMNA | |
| SCHEMBL7699541 | 0.83 | PDE10A (0.55) | SMN1; SMN2USP2RECQLGPR119PIK3CA | |
| SCHEMBL30592010 | 0.82 | POLB (0.60) | SMN1; SMN2GPR119MAPTALDH1A1LMNA | |
| SCHEMBL7061217 | 0.82 | GPR119 (0.49) | GPR119MAPTALDH1A1LMNAPOLB | |
| SCHEMBL124268 | 0.82 | POLB (0.60) | SMN1; SMN2GPR119MAPTALDH1A1LMNA | |
| SCHEMBL31651955 | 0.81 | GPR119 (0.49) | GPR119MAPTALDH1A1LMNAPOLB | |
| SCHEMBL26107084 | 0.81 | KIT (0.48) | GPR119MAPTALDH1A1LMNAPOLB | |
| SCHEMBL31727610 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2USP2RECQLMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112154145-B | Piperazine azaspiro derivatives | 辉瑞大药厂 | 2023-10-17 | — | — | CN | disclosed |
| CN-112154145-A | Piperazine azaspiro derivatives | 辉瑞大药厂 | 2020-12-29 | — | — | CN | disclosed |