Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL124268 | 1.00 | POLB (0.60) | POLBGPR119TRPA1TRPV1MEN1 | |
| SCHEMBL5236520 | 0.95 | POLB (0.55) | POLBGPR119TRPA1TRPV1MEN1 | |
| SCHEMBL23560764 | 0.84 | GPR119 (0.50) | POLBGPR119MEN1KMT2APDE10A | |
| SCHEMBL122648 | 0.84 | PDE10A (0.53) | POLBGPR119PDE10AKITCKS1B | |
| SCHEMBL2385593 | 0.84 | GPR119 (0.50) | POLBGPR119PDE10AKITCKS1B | |
| SCHEMBL7061217 | 0.83 | GPR119 (0.49) | POLBGPR119PDE10AKITCKS1B | |
| SCHEMBL2421627 | 0.83 | TRPA1 (0.68) | POLBGPR119TRPA1TRPV1 | |
| SCHEMBL3667084 | 0.82 | MEN1 (0.53) | POLBGPR119TRPA1TRPV1MEN1 | |
| SCHEMBL31651955 | 0.82 | GPR119 (0.49) | POLBGPR119PDE10AKITCKS1B | |
| SCHEMBL28501446 | 0.82 | SMN1; SMN2 (0.59) | POLBGPR119MEN1KMT2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4496570-A2 | SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS | The Scripps Research Institute (US) | 2025-01-29 | — | — | EP | disclosed |
| WO-2023183768-A2 | SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-09-28 | — | — | WO | disclosed |