Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.39 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854046 | 0.90 | MAPT (0.44) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2855568 | 0.89 | KEAP1 (0.42) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2860433 | 0.85 | MAPT (0.48) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2855562 | 0.83 | MAPT (0.46) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10366979 | 0.82 | KEAP1 (0.53) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1335647 | 0.80 | MAPT (0.68) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL29419571 | 0.80 | MAPT (0.68) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL31684401 | 0.78 | MAPT (0.51) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL30147333 | 0.78 | MAPT (0.51) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10364566 | 0.75 | KDM4E (0.52) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |