Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.38 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.38 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860433 | 0.87 | MAPT (0.48) | MAPTPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2854046 | 0.84 | MAPT (0.44) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2850160 | 0.83 | MAPT (0.43) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2855568 | 0.77 | KEAP1 (0.42) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2856196 | 0.75 | MAPT (0.70) | MAPTPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2855560 | 0.75 | ALDH1A1 (0.49) | MAPTPOLBSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL2854456 | 0.72 | MEN1 (0.47) | MAPTPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2858117 | 0.71 | MAPT (0.41) | MAPTPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10365422 | 0.71 | MAPT (0.67) | MAPTPOLBSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL2850244 | 0.70 | MALT1 (0.51) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |