Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.65 |
| ▸ | AURKA | O14965 | 9/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6256569 | 0.82 | AURKA (0.72) | KDM5BAURKATP53MAPTLMNA | |
| SCHEMBL976547 | 0.81 | AURKA (0.74) | KDM5BAURKATP53MAPTLMNA | |
| SCHEMBL22095269 | 0.79 | AURKA (1.00) | KDM5BAURKATP53MAPTLMNA | |
| SCHEMBL4501557 | 0.77 | ALDH1A1 (0.82) | KDM5BAURKATP53MAPTLMNA | |
| SCHEMBL12264890 | 0.77 | MAPT (1.00) | KDM5BAURKATP53MAPTLMNA | |
| SCHEMBL14132504 | 0.76 | TP53 (0.73) | KDM5BAURKATP53MAPTLMNA | |
| SCHEMBL22095286 | 0.76 | KDM5B (0.95) | KDM5BAURKATP53MAPTLMNA | |
| SCHEMBL14132445 | 0.75 | KDM5B (0.69) | KDM5BAURKATP53MAPTLMNA | |
| SCHEMBL28771391 | 0.75 | ALDH1A1 (0.78) | KDM5BAURKATP53MAPTLMNA | |
| SCHEMBL5812722 | 0.75 | MAPT (0.67) | KDM5BAURKATP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109970654-B | A series of substituted 2-phenyl pyrazole derivatives, and preparation method and application thereof | 郑州大学 | 2020-12-25 | — | — | CN | disclosed |