Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.60 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976547 | 0.87 | AURKA (0.74) | AURKATP53MAPTKDM5BLMNA | |
| SCHEMBL23928535 | 0.86 | AURKA (0.78) | AURKATP53MAPTLMNAGAA | |
| SCHEMBL22095269 | 0.84 | AURKA (1.00) | AURKATP53MAPTKDM5BLMNA | |
| SCHEMBL4501557 | 0.83 | ALDH1A1 (0.82) | AURKATP53MAPTKDM5BLMNA | |
| SCHEMBL28501937 | 0.82 | KDM5B (0.65) | AURKATP53MAPTKDM5BLMNA | |
| SCHEMBL12264890 | 0.82 | MAPT (1.00) | AURKATP53MAPTKDM5BLMNA | |
| SCHEMBL14132504 | 0.82 | TP53 (0.73) | AURKATP53MAPTKDM5BLMNA | |
| SCHEMBL22095286 | 0.81 | KDM5B (0.95) | AURKATP53MAPTKDM5BLMNA | |
| SCHEMBL14132445 | 0.80 | KDM5B (0.69) | AURKATP53MAPTKDM5BLMNA | |
| SCHEMBL5812722 | 0.80 | MAPT (0.67) | AURKATP53MAPTKDM5BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005061462-A2 | DIARYL PYRAZOLE DERIVATIVES AND THEIR USE AS NEUROKININ-3 RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |