Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | GSR | P00390 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.43 |
| ▸ | EPOR | P19235 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9187784 | 0.88 | ALDH1A1 (0.61) | ALDH1A1LTA4HMMP2SLC1A1SLC1A3 | |
| Lysine SCHEMBL1133708 | 0.86 | SLC1A3 (0.52) | GSRLTA4HMMP2SLC1A1SLC1A3 | |
| SCHEMBL730307 | 0.84 | LTA4H (0.57) | ALDH1A1GSRLTA4HMMP2SLC1A1 | |
| SCHEMBL676143 | 0.84 | LTA4H (0.57) | ALDH1A1GSRLTA4HMMP2SLC1A1 | |
| Hydrochloric Acid SCHEMBL29401201 | 0.83 | LTA4H (0.56) | ALDH1A1GSRLTA4HMMP2SLC1A1 | |
| SCHEMBL8618743 | 0.83 | LTA4H (0.56) | ALDH1A1GSRLTA4HMMP2ITGB3 | |
| Hydrochloric Acid SCHEMBL9394090 | 0.83 | LTA4H (0.56) | ALDH1A1GSRLTA4HMMP2SLC1A1 | |
| Hydrochloric Acid SCHEMBL9394094 | 0.83 | LTA4H (0.56) | ALDH1A1GSRLTA4HMMP2SLC1A1 | |
| Hydrochloric Acid SCHEMBL6671170 | 0.82 | LTA4H (0.55) | GSRLTA4HMMP2ITGB3ITGA2B | |
| Serine SCHEMBL28148320 | 0.81 | ALDH1A1 (0.69) | ALDH1A1LTA4HSLC1A1SLC1A3ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105273060-B | Lysine single methylation derivatization modified antibody and preparation method thereof | 杭州景杰生物科技股份有限公司 | 2022-07-19 | — | — | CN | disclosed |
| CN-108084047-B | Method for preparing specific propionyl methylated lysine pan-antibody | 杭州景杰生物科技有限公司 | 2020-12-15 | — | — | CN | disclosed |