Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 8/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29242138 | 0.81 | XPO1 (0.47) | XPO1CNR2 | |
| SCHEMBL855385 | 0.76 | XPO1 (0.43) | XPO1CACNA1BCACNA1CCACNA1GHTT | |
| SCHEMBL27627602 | 0.75 | XPO1 (0.42) | XPO1HTT | |
| SCHEMBL22028970 | 0.75 | XPO1 (0.49) | XPO1CACNA1BCACNA1CCACNA1GHTT | |
| SCHEMBL29028016 | 0.74 | SSTR4 (0.34) | — | |
| SCHEMBL28379002 | 0.74 | AKT1 (0.36) | HTR2CSLC6A4HDAC1CNR2 | |
| SCHEMBL22029019 | 0.74 | XPO1 (0.48) | XPO1CACNA1BCACNA1CCACNA1GHTT | |
| SCHEMBL30911244 | 0.74 | XPO1 (0.48) | XPO1CACNA1BCACNA1CCACNA1GHTT | |
| SCHEMBL28512757 | 0.72 | XPO1 (0.45) | XPO1HTT | |
| SCHEMBL28176575 | 0.68 | AKT1 (0.41) | XPO1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112105419-B | Condensed ring compound | 豪夫迈·罗氏有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-112105419-A | Fused ring compound | 豪夫迈·罗氏有限公司 | 2020-12-18 | — | — | CN | disclosed |