Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | GRK2 | P25098 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.46 |
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555316 | 0.87 | PTPN7 (0.55) | ROCK2ROCK1KDM4EMEN1KMT2A | |
| SCHEMBL30025182 | 0.87 | PTPN7 (0.55) | ROCK2ROCK1KDM4EMEN1KMT2A | |
| SCHEMBL16179479 | 0.82 | ALDH1A1 (0.52) | ROCK2ROCK1KDM4EMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL20974298 | 0.80 | PTPN7 (0.48) | ROCK2ROCK1KDM4EMEN1KMT2A | |
| SCHEMBL20999628 | 0.80 | MEN1 (0.48) | ROCK2ROCK1KDM4EMEN1KMT2A | |
| SCHEMBL20973915 | 0.78 | ATF4 (0.53) | MEN1KMT2APOLB | |
| SCHEMBL28496067 | 0.78 | MEN1 (0.43) | KDM4EMEN1KMT2AMAPTPKM | |
| SCHEMBL30075985 | 0.78 | ATF4 (0.53) | MEN1KMT2APOLB | |
| SCHEMBL16711152 | 0.76 | FGFR2 (0.71) | KDM4EMEN1KMT2AMAPTPKM | |
| SCHEMBL8059741 | 0.76 | PDE3B (0.52) | ROCK2ROCK1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115947681-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-109641844-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-112189008-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2021-01-05 | — | — | CN | disclosed |