Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PRF1 | P14222 | 3/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28506377 | 0.95 | PTPN11 (0.45) | PTPN11L3MBTL1PRF1MAPTRECQL | |
| SCHEMBL28509537 | 0.86 | PTPN11 (0.45) | PTPN11L3MBTL1BRD4ENPP3ENPP1 | |
| SCHEMBL31396616 | 0.83 | PTPN11 (0.53) | PTPN11L3MBTL1MAPTBRD4ENPP3 | |
| SCHEMBL28510061 | 0.81 | PTPN11 (0.49) | PTPN11CYP11B1CYP11B2HTR6 | |
| SCHEMBL7905360 | 0.80 | PTPN11 (0.46) | PTPN11L3MBTL1MAPTRECQLBRD4 | |
| SCHEMBL31344454 | 0.79 | PTPN11 (0.50) | PTPN11L3MBTL1MAPTENPP3ENPP1 | |
| SCHEMBL721024 | 0.79 | HTR6 (0.46) | PTPN11HTR6 | |
| SCHEMBL31396524 | 0.78 | PTPN11 (0.52) | PTPN11L3MBTL1MAPTBRD4ENPP3 | |
| SCHEMBL31396517 | 0.78 | PTPN11 (0.49) | PTPN11L3MBTL1MAPTBRD4GRM5 | |
| SCHEMBL720190 | 0.78 | PTPN11 (0.49) | PTPN11L3MBTL1MAPTCYP3A4ENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |