Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907052 | 0.89 | PTPN11 (0.46) | PTPN11L3MBTL1PIK3CDCA1CA2 | |
| SCHEMBL7910236 | 0.86 | PTPN11 (0.40) | PTPN11L3MBTL1PIK3CDCA1CA2 | |
| SCHEMBL12066674 | 0.86 | PTPN11 (0.49) | PTPN11L3MBTL1PIK3CDCYP11B1CYP11B2 | |
| SCHEMBL7907976 | 0.85 | PTPN11 (0.50) | PTPN11L3MBTL1PIK3CDCYP11B1CYP11B2 | |
| SCHEMBL31396616 | 0.84 | PTPN11 (0.53) | PTPN11L3MBTL1CA1CA2ENPP3 | |
| SCHEMBL12066665 | 0.83 | MAP3K11 (0.47) | PTPN11PIK3CDIDO1IKBKBCHUK | |
| SCHEMBL12066045 | 0.82 | PTPN11 (0.47) | PTPN11HTR6BRD4 | |
| SCHEMBL31344454 | 0.80 | PTPN11 (0.50) | PTPN11L3MBTL1ENPP3ENPP1MEN1 | |
| SCHEMBL28503544 | 0.80 | PTPN11 (0.44) | PTPN11L3MBTL1CYP11B1CYP11B2ENPP3 | |
| SCHEMBL31396515 | 0.80 | PTPN11 (0.47) | PTPN11L3MBTL1PIK3CDCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149950-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |