Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 6/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28509455 | 0.90 | BRD4 (0.59) | INSRCDK2FLT3ABL1IKBKB | |
| SCHEMBL28502371 | 0.89 | MAP4K1 (0.52) | INSRCDK2FLT3ABL1IKBKB | |
| SCHEMBL29086584 | 0.86 | PIK3CA (0.54) | INSRCDK2FLT3CDK8AXL | |
| SCHEMBL28506118 | 0.85 | DYRK1A (0.51) | INSRCDK2FLT3ABL1IKBKB | |
| SCHEMBL28502161 | 0.84 | BRD4 (0.64) | INSRCDK2FLT3ABL1IKBKB | |
| SCHEMBL28507231 | 0.84 | CDK8 (0.45) | INSRCDK2FLT3ABL1IKBKB | |
| SCHEMBL28502063 | 0.83 | CDK8 (0.52) | INSRCDK2FLT3ABL1IKBKB | |
| SCHEMBL28499630 | 0.82 | FLT3 (0.56) | INSRCDK2FLT3ABL1IKBKB | |
| SCHEMBL29889598 | 0.81 | DYRK1A (0.56) | INSRCDK2FLT3ABL1IKBKB | |
| SCHEMBL28504401 | 0.81 | MAPK1 (0.55) | PIK3CGPIK3CADYRK1APIK3CDRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119707930-A | Aromatic ring compound and its prepn and use | 甘李药业股份有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-116848113-A | Bicyclic compounds as HPK1 inhibitors and application thereof | 南京再明医药有限公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022228522-A1 | ALKYNE COMPOUND AS HPK1 INHIBITOR AND USE THEREOF | 江苏先声药业有限公司 | 2022-11-03 | — | — | WO | disclosed |
| WO-2022171034-A1 | BICYCLIC COMPOUND AS HPK1 INHIBITOR AND APPLICATION THEREOF | 江苏先声药业有限公司 | 2022-08-18 | — | — | WO | disclosed |
| CN-114685489-A | Polysubstituted nitrogen-containing heterocyclic compound and application thereof | 江苏先声药业有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |