Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.54 |
| ▸ | MTOR | P42345 | 5/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.54 |
| ▸ | PLK4 | O00444 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | ROS1 | P08922 | 2/20 | 0.54 |
| ▸ | MARK3 | P27448 | 2/20 | 0.54 |
| ▸ | FLT4 | P35916 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | CLK2 | P49760 | 2/20 | 0.54 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.54 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28504203 | 0.86 | INSR (0.49) | PIK3CAMTORPIK3CDPLK4MAP4K4 | |
| SCHEMBL29652420 | 0.82 | PLK4 (0.58) | PIK3CAMTORPIK3CDPLK4MAP4K4 | |
| SCHEMBL28502371 | 0.79 | MAP4K1 (0.52) | PIK3CAMTORPIK3CDFLT3CDK8 | |
| SCHEMBL29652484 | 0.78 | PLK4 (0.56) | PIK3CAMTORPIK3CDPLK4MAP4K4 | |
| SCHEMBL5437082 | 0.78 | PLK4 (0.65) | PIK3CAMTORPIK3CDPLK4MAP4K4 | |
| SCHEMBL28509455 | 0.78 | BRD4 (0.59) | PIK3CAMTORPIK3CDKDRFGFR1 | |
| SCHEMBL29086742 | 0.76 | MAP4K1 (0.48) | PIK3CAMTORPIK3CDBRD4PIK3CG | |
| SCHEMBL29888822 | 0.76 | MAP4K1 (0.48) | PIK3CAMTORPIK3CDBRD4PIK3CG | |
| SCHEMBL856151 | 0.76 | PIK3CA (0.51) | PIK3CAMTORPIK3CDPLK4MAP4K4 | |
| SCHEMBL12821628 | 0.75 | PIK3CA (0.54) | PIK3CAMTORPIK3CDPLK4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116848113-A | Bicyclic compounds as HPK1 inhibitors and application thereof | 南京再明医药有限公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022171034-A1 | BICYCLIC COMPOUND AS HPK1 INHIBITOR AND APPLICATION THEREOF | 江苏先声药业有限公司 | 2022-08-18 | — | — | WO | disclosed |