Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.64 |
| ▸ | F10 | P00742 | 1/20 | 0.63 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.63 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.63 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA6 | P23280 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035260 | 0.86 | AKR1C3 (0.63) | MAPK1KMT2ATDP1AKR1C3F10 | |
| SCHEMBL2850435 | 0.84 | PRMT1 (0.83) | MAPK1KMT2ATDP1AKR1C3F10 | |
| SCHEMBL2858650 | 0.82 | AKR1C3 (0.80) | MAPK1KMT2ATDP1AKR1C3F10 | |
| SCHEMBL5034887 | 0.81 | CYP2C19 (0.76) | MAPK1KMT2ATDP1AKR1C3F10 | |
| SCHEMBL6804085 | 0.79 | PRMT1 (0.88) | KMT2ATDP1PRMT1HTTCA1 | |
| SCHEMBL2859691 | 0.77 | CYP2C19 (0.55) | MAPK1KMT2ATDP1AKR1C3F10 | |
| SCHEMBL7516260 | 0.77 | AKR1C3 (0.76) | MAPK1KMT2ATDP1AKR1C3F10 | |
| SCHEMBL2850555 | 0.76 | LMNA (0.53) | MAPK1KMT2ATDP1AKR1C3PRSS1 | |
| Hydrochloric Acid SCHEMBL7517991 | 0.76 | F10 (0.98) | MAPK1KMT2ATDP1AKR1C3F10 | |
| SCHEMBL17713153 | 0.76 | CYP2C19 (0.53) | MAPK1KMT2ATDP1AKR1C3F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |