Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.55 |
| ▸ | LPL | P06858 | 10/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 10/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25475421 | 0.88 | DGAT1 (0.55) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL2066133 | 0.87 | DGAT1 (0.56) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL29631065 | 0.85 | DGAT1 (0.58) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL2584006 | 0.85 | DGAT1 (0.58) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL1284745 | 0.85 | DGAT1 (0.58) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL10224532 | 0.85 | DGAT1 (0.55) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL1284321 | 0.85 | DGAT1 (0.55) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL21327400 | 0.84 | DGAT1 (0.57) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL4046507 | 0.83 | DGAT1 (0.57) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL153339 | 0.83 | DGAT1 (0.59) | DGAT1LPLLIPGCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |